Distinct germ-line genetic mutation patterns correlate with reproductive outcomes in ICSI patients: a pilot study
This pilot study suggests that direct sperm exome sequencing may reveal genetic variants associated with different ICSI outcomes. While our findings require validation in larger cohorts, they generate hypotheses about sperm-specific factors that might influence post-fertilization developmental events and pregnancy outcomes.
Authors
- Sixian Wu (ORCID: https://orcid.org/0000-0001-9396-9635)
- Wen‐Bin Wu (ORCID: https://orcid.org/0000-0001-9248-5030)
- Shilong Wang (ORCID: https://orcid.org/0000-0001-6086-0481)
- Wenming Xu (ORCID: https://orcid.org/0000-0002-3686-229X)
- Ting Jiang (ORCID: https://orcid.org/0000-0002-9523-4058)
- Qiwen Yang (ORCID: https://orcid.org/0009-0006-0195-4342)
- Xueguang Zhang (ORCID: https://orcid.org/0000-0001-5458-8354)
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fgene.2025.1610943
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Development and Reform Commission
- National Key Research and Development Program of China