TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury
These findings not only underscore the crucial role of TSLP in the regulation of sepsis-associated ARDS but also demonstrate its potential clinical value as both a predictive biomarker for early detection and a molecular target for therapeutic intervention.
Authors
- Xiufang Weng (ORCID: https://orcid.org/0000-0003-2625-2137)
- Ting Zhou (ORCID: https://orcid.org/0000-0001-7096-7610)
- Younian Xu (ORCID: https://orcid.org/0000-0001-8984-5883)
- Meiying Wang (ORCID: https://orcid.org/0000-0003-3563-9974)
- Mi Wu
- Ziyao Zhang (ORCID: https://orcid.org/0009-0009-8377-6173)
- Yawen Zhan
Institutions
- Union Hospital (HK)
- Ministry of Education of the People's Republic of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Health and Family Planning Commission (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1583235
- Citations
- 2
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- University of Science and Technology of China
- National Health Commission of the People's Republic of China