Ferroptosis and ageing

Ferroptosis is a regulated form of cell death characterized by iron-dependent lipid peroxidation. Since its initial description, it has garnered significant attention due to its implications in various diseases, including cancer, neurodegeneration, and ischemia-reperfusion injury. The ageing process is characterized by a progressive decline in cellular function and increased susceptibility to oxidative damage, both of which intersect with ferroptosis pathways. This review explores the intricate relationship between ferroptosis and ageing, focusing on molecular mechanisms, the role of iron metabolism, implications in age-related diseases, and potential therapeutic strategies. By understanding the interplay between ferroptosis and ageing, researchers can uncover novel targets for promoting healthy ageing and mitigating age-associated disorders.