Integrating Mendelian randomization and multi-transcriptomic analyses to unveil the genetic association risk of regulatory T cell-mediated free cholesterol and gastric cancer
Our analysis indicates a causal relationship between free cholesterol levels and gastric cancer, with regulatory T cells acting as mediators. Modulating free cholesterol levels to influence regulatory T cells may offer new insights and prospects for the prevention and treatment of gastric cancer.
Authors
- Fanyu Peng
- Yanhong Luo (ORCID: https://orcid.org/0000-0002-0943-4169)
- Yizhi Ge (ORCID: https://orcid.org/0000-0001-8349-0970)
- Haitao Liu (ORCID: https://orcid.org/0000-0002-3674-0081)
- Yesong Guo
- Jing Wen
Institutions
- Inner Mongolia University (CN)
- Jiangsu Cancer Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1007/s12672-025-02739-1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Cancer Hospital