Postmortem Inductively Coupled Plasma Mass Spectrometry Analysis Reveals Elevated Heavy Metal Concentrations in Coronary Arteries: A Comparative Autopsy Study Supporting a Toxic Inflammatory Hypothesis for Atherosclerosis
Heavy metals through inflammation, oxidative stress, and disrupted antioxidant pathways are independent risk factors that increase the risk of atherosclerosis. These findings provide tissue-level evidence that heavy metal accumulation may contribute to atherosclerosis through oxidative stress, inflammation, and disruption of antioxidant defenses.
Authors
- Ayhan Olcay (ORCID: https://orcid.org/0000-0003-0525-6569)
- Doğaç Ökşen
- Erdem Tezcan
- Emir Cantürk (ORCID: https://orcid.org/0000-0003-1485-0009)
- Özge Çetinarslan (ORCID: https://orcid.org/0000-0003-4825-6489)
- Esra E. Kasapbasi (ORCID: https://orcid.org/0000-0002-5854-3580)
- Onur Yolay
- Bekir İnan (ORCID: https://orcid.org/0000-0003-1719-131X)
- Serdar Baki Albayrak (ORCID: https://orcid.org/0000-0002-9221-975X)
- Ceyhun Küçük
- Hasan Karaoglu
- F. Umihanić
Institutions
- Istanbul Bilim University (TR)
- Haliç University (TR)
- Bezmiâlem Vakıf Üniversitesi (TR)
- Istanbul Medipol University (TR)
- Istanbul University-Cerrahpaşa (TR)
- Ministry of Justice (TR)
- 77 Elektronika (Hungary) (HU)
- Altınbaş University (TR)
- Boğaziçi University (TR)
- Istanbul Technical University (TR)
- Istanbul University (TR)
Publication Details
- Journal
- Biomedicine Hub
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1159/000546499
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00