The maternal exposure of digoxin and flecainide in relation to the safety and effectiveness in the treatment of non-hydropic fetal tachycardia
Digoxin monotherapy successfully treated fetal tachycardia in only 32% of cases. Adding flecainide improved response to 93%, although it increased side effects, which could be managed with dose reductions. Maternal digoxin levels were stable throughout pregnancy.
Authors
- Jolien W. Roos‐Hesselink (ORCID: https://orcid.org/0000-0002-6770-3830)
- Marieke M. Beex‐Oosterhuis (ORCID: https://orcid.org/0000-0002-3070-3626)
- Johanna A van der Zande (ORCID: https://orcid.org/0000-0002-9569-6551)
- Robert B. Flint (ORCID: https://orcid.org/0000-0002-3658-594X)
- Charlotte van Kesteren (ORCID: https://orcid.org/0000-0001-9071-6421)
- Jerome M J Cornette (ORCID: https://orcid.org/0000-0001-8482-5138)
- Ingrid M. van Beynum
- Rosa M A Smeets
Institutions
- Erasmus MC (NL)
- Albert Schweitzer Ziekenhuis (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
Publication Details
- Journal
- Heart Rhythm
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1016/j.hrthm.2025.05.039
- Citations
- 2
- Primary Topic
- Cardiovascular Issues in Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 2.78