IL-6 decodes sex and diet-dependent circadian and metabolic rhythms
These findings identify IL-6 as a critical mediator of circadian-metabolic plasticity, shaping sex- and diet-specific trade-offs between circadian stability and metabolic homeostasis. Our study highlights IL-6 as a potential therapeutic target for mitigating circadian misalignment-associated metabolic disorders, with implications for the timed modulation of IL-6 signaling.
Authors
- Antonio Díaz‐López (ORCID: https://orcid.org/0000-0003-0103-3296)
- Claes Ohlsson
- María Luz García‐García (ORCID: https://orcid.org/0000-0003-4906-4227)
- Beatriz Fernández‐Rodríguez (ORCID: https://orcid.org/0000-0001-9676-2883)
- Manuel Tena‐Sempere (ORCID: https://orcid.org/0000-0002-4741-5567)
- Olga Barca‐Mayo (ORCID: https://orcid.org/0000-0002-2335-7980)
- Matti Poutanen (ORCID: https://orcid.org/0000-0002-8953-1734)
- María Luengo-Mateos
- Antía González-Vila
- Carlos Diéguez-González
- Ali Mohammad Ibrahim-Alasoufi
- Víctor Pardo-García
Institutions
- University of Turku (FI)
- Instituto de Salud Carlos III (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- University of Gothenburg (SE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1016/j.molmet.2025.102171
- Citations
- 1
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Ministerio de Ciencia e Innovación
- Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia
- Xunta de Galicia
- Agencia Estatal de Investigación