Nickel-Catalyzed C(sp<sup>3</sup>)–C(sp<sup>3</sup>) Cross-Coupling of Carboxamides and Unactivated Alkyl Iodides
The construction of C(sp<sup>3</sup>)-C(sp<sup>3</sup>) bonds through cross-coupling reactions of unactivated alkyl halides and C-radical precursors presents a significant challenge in organic synthesis. Herein, we report a strategy for the formation of C(sp<sup>3</sup>)-C(sp<sup>3</sup>) bonds using alkyl halides as alkylation reagents via the 1,5-hydrogen atom transfer (HAT) process. The reactions proceed under mild conditions, demonstrating a remarkable tolerance for a diverse array of functional groups. This method possesses the potential to expand new pathways in organic synthesis.
Authors
- Rui-Qiang Jiao
- Xi Chen (ORCID: https://orcid.org/0000-0002-2974-9977)
- Tian Ding
- Guohua Ren (ORCID: https://orcid.org/0000-0001-6464-994X)
- Xue‐Yuan Liu (ORCID: https://orcid.org/0000-0002-8862-9924)
- Haochen Li (ORCID: https://orcid.org/0000-0002-4475-0984)
Institutions
- Lanzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1021/acs.joc.5c00572
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China