Effect of acute exercise and exercise training on the ability of insulin to clear branched-chain amino acids from plasma in obesity and type 2 diabetes
Our results demonstrate that insulin's ability to suppress plasma BCAAs is impaired in type 2 diabetes but is intact in individuals with obesity. Although acute exercise reduces fasting BCAA levels, neither acute exercise nor exercise training affects insulin's ability to suppress plasma BCAAs in glucose-tolerant individuals with or without obesity or in individuals with type 2 diabetes.
Authors
- Rasmus Kjøbsted (ORCID: https://orcid.org/0000-0002-0628-4994)
- Kurt Højlund (ORCID: https://orcid.org/0000-0002-0891-4224)
- Jørgen F. P. Wojtaszewski (ORCID: https://orcid.org/0000-0001-8185-3408)
- Pauline M. Møller (ORCID: https://orcid.org/0000-0002-0086-2204)
- Martin Eisemann de Almeida
- Maria Houborg Petersen
- Andreas James Thestrup Pedersen
Institutions
- University of Copenhagen (DK)
- Steno Diabetes Centers (DK)
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1007/s00125-025-06454-y
- Citations
- 5
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Savvaerksejer Jeppe Juhl og Hustru Ovita Juhls Mindelegat
- European Foundation for the Study of Diabetes
- Novo Nordisk
- Odense Universitetshospital
- Danmarks Frie Forskningsfond
- Syddansk Universitet
- Novo Nordisk Fonden
- Diabetesforeningen
- Medical Research Council