Luminal Transcription Factor Hierarchy Shapes the AR Cistrome in Prostate Cancer

The recruitment of the androgen receptor to lineage-defining enhancers depends on the cooperation of several luminal transcription factors to facilitate opening of the chromatin; however, their pioneer function has not been fully described. In this manuscript, Keo et al. showed that FOXA1 alone pioneers androgen receptor recruitment while HOXB13 and GATA2 serve as cofactors, illustrating a hierarchical relationship between these TFs in AR pathway active prostate cancer (ARPC).