HPV-associated squamous cell carcinoma and adenocarcinoma in distinct cervical sites: a case report
A 54-year-old female tested HPV type 18 positive in a routine physical exam. Cervical Liquid - based Cytology Test (LCT) showed Atypical Squamous Cells of Undetermined Significance (ASCUS). Colposcopy-directed biopsies revealed moderately differentiated squamous cell carcinoma at multiple sites (3, 6, 9, 12 o'clock positions and the ECC), with a clinical diagnosis of stage IA1. Preoperative abdominal MRI (including contrast enhancement) showed no lymph node enlargement, and urinary CT urography was normal. Squamous cell carcinoma antigen levels were within the normal range.
Authors
- Hao Zhang (ORCID: https://orcid.org/0000-0001-5973-7080)
- Donghan Xu (ORCID: https://orcid.org/0000-0002-9813-3471)
- Donghui Huang (ORCID: https://orcid.org/0000-0002-0174-7187)
- Min Kang (ORCID: https://orcid.org/0000-0003-2287-8757)
- Liqi Li (ORCID: https://orcid.org/0000-0003-1383-4082)
- Bowen Wu (ORCID: https://orcid.org/0000-0003-1759-9729)
- Jiaxin Li (ORCID: https://orcid.org/0000-0002-4373-9695)
- Yuhong Zheng
- Huihui Chen (ORCID: https://orcid.org/0000-0002-2321-4349)
- Jiaqi Zhou (ORCID: https://orcid.org/0000-0001-6561-1337)
- Peiyu Yan (ORCID: https://orcid.org/0000-0002-9372-4803)
- Wei Huang (ORCID: https://orcid.org/0000-0002-7279-0932)
- Yihao Niu
- Lin Zhao
- Xin Lin
- Qingyi Wang (ORCID: https://orcid.org/0000-0002-1071-5179)
Institutions
- Macau University of Science and Technology (MO)
- Shenzhen Sixth People's Hospital (CN)
- Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s12879-025-11114-y
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00