Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant Properties
The antioxidant properties of novel diiodo-substituted 3-dithiocarbamic flavanones were investigated. The three frameworks that proved to be the most active ones in our previous studies were selected. By varying the nature of the substituent at the para position of flavanone ring <b>B</b>, a structure-activity relationship study on radical scavenging properties was performed. The influence of these substituents (F, Cl, Br and H) was investigated against DPPH and ABTS<sup>+•</sup>. The results indicate that the presence of the halogen substituents induces better antioxidant properties than ascorbic acid and BHT. The highest radical scavenging activity was found in the case of morpholine carbodithioates. Regarding the ABTS<sup>+•</sup> assay, all investigated flavanones exhibited better antioxidant properties than BHT.
Authors
- M. L. Birsa (ORCID: https://orcid.org/0000-0003-4483-873X)
- Laura G. Sârbu (ORCID: https://orcid.org/0000-0003-1789-2108)
Institutions
- Alexandru Ioan Cuza University (RO)
Publication Details
- Journal
- Molecules
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3390/molecules30112280
- Primary Topic
- Synthesis of Organic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerul Cercetării, Inovării şi Digitalizării
- Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii
- Colegiul Consultativ pentru Cercetare-Dezvoltare şi Inovare