Investigating the associations of blood lead and cadmium with smoking-related DNA methylation and mortality among U.S. adults
Drawing from a nationally representative cohort of older U.S. adults, this study provides robust evidence linking blood lead and cadmium levels to smoking-related DNAm and increased mortality risk. Moreover, the analysis revealed additive effects of these metals on smoking-related DNAm, as well as synergistic impacts on all-cause mortality. Additionally, smoking-induced DNAm may play a role in mediating the connection between heavy metal exposure and mortality risk. Additional research is required to investigate the underlying mechanisms of these associations.
Authors
- Ta‐Chen Su (ORCID: https://orcid.org/0000-0001-7523-7166)
- Chien‐Yu Lin (ORCID: https://orcid.org/0000-0002-6184-8852)
- Yu‐Wei Fang (ORCID: https://orcid.org/0000-0002-1302-1885)
- Chikang Wang (ORCID: https://orcid.org/0000-0002-2947-8206)
- Ching‐Way Chen (ORCID: https://orcid.org/0000-0002-8516-4308)
Institutions
- Fu Jen Catholic University (TW)
- Yuanpei University (TW)
- National Taiwan University Hospital (TW)
- Memorial Hospital (US)
- National Yunlin University of Science and Technology (TW)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.118360
- Citations
- 2
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- Shin Kong Wu Ho-Su Memorial Hospital