Engineered biosynthesis and characterization of disaccharide-pimaricin
This study underscores the potential of disaccharide polyene macrolides as safer antifungal agents and establishes a robust framework for engineering strains to produce these compounds. The findings provide critical insights into balancing biosynthetic efficiency and strain fitness, advancing the development of next-generation polyene antibiotics.
Authors
- Xingzhong Jin (ORCID: https://orcid.org/0000-0003-4293-8665)
- Yao Dong (ORCID: https://orcid.org/0000-0002-6399-6517)
- Xi Zuo
- Zhongyuan Ren (ORCID: https://orcid.org/0000-0002-0300-7801)
- Liqin Qiao
- Hao Cui (ORCID: https://orcid.org/0009-0001-3539-7138)
Institutions
- Beihua University (CN)
- Jilin University of Chemical Technology (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s12934-025-02742-9
- Primary Topic
- Plant tissue culture and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- People's Government of Jilin Province
- Education Department of Jilin Province
- Department of Science and Technology of Jilin Province
- Jilin Institute of Chemical Technology