Neuroimaging and plasma biomarker differences and commonalities in Lewy body dementia subtypes
Plasma neurofilament light and phosphorylated tau-217 were increased in Lewy body dementia (LBD) relative to Parkinson's disease (PD) and controls. Magnetic resonance imaging (MRI) white matter macrostructure (fiber cross-section) was reduced in LBD relative to PD. In contrast, MRI white matter microstructure (fiber density) was reduced in PD dementia compared to dementia with Lewy bodies. Differences between dementia with Lewy bodies and PD dementia were distinct compared with those between LBD and Parkinson's with normal cognition. Our findings suggest that dementia with Lewy bodies and Parkinson's dementia differ in underlying processes distinct from those driving dementia.
Authors
- Angeliki Zarkali (ORCID: https://orcid.org/0000-0003-2808-072X)
- Elena Veleva
- Ivelina Dobreva (ORCID: https://orcid.org/0000-0002-9401-1899)
- Naomi Hannaway (ORCID: https://orcid.org/0000-0001-8608-7757)
- Rohan Bhome (ORCID: https://orcid.org/0000-0002-8317-7930)
- Amanda Heslegrave (ORCID: https://orcid.org/0000-0002-7290-6405)
- Rimona Sharon Weil (ORCID: https://orcid.org/0000-0002-5092-6325)
- George E. Thomas (ORCID: https://orcid.org/0000-0001-6107-0326)
- Katie Tucker (ORCID: https://orcid.org/0009-0009-0349-3107)
- Henrik Zetterberg
- Irene Gorostiaga Belio
Institutions
- Wellcome Centre for Human Neuroimaging (GB)
- Sahlgrenska University Hospital (SE)
- UK Dementia Research Institute (GB)
- The London College (GB)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70274
- Citations
- 9
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.50
Funders
- Johns Hopkins University
- Wellcome Trust
- Parkinson's UK
- Rosetrees Trust
- Eisai
- University College London Hospitals NHS Foundation Trust
- UCLH Biomedical Research Centre