Three new diterpenoids from the aerial parts of <i>Callicarpa macrophylla</i>

Three previously unreported diterpenoids, <i>iso</i>-gaultheric acid (<b>1</b>), 7<i>α</i>-hydroxy-karamatsuic acid (<b>2</b>) and <i>iso</i>-bodinieric acid J (<b>3</b>), along with seven known diterpenoids (<b>4-10</b>), were yielded from the 95% ethanol extract of the aerial parts of <i>Callicarpa macrophylla</i> Vahl. The elucidation of their structure was accomplished through integrated interpretation of physicochemical characteristics combined with multi-spectral investigations, including 1D/2D NMR, ECD and HR-ESI-MS. Anti-inflammatory activity tests were conducted on the compounds <b>3</b>-<b>9</b>, revealing that <b>6</b> inhibited LDH release with an IC₅₀ value of 14.79 ± 2.69 µM.