Heterogeneity in response to GLP-1 receptor agonists in type 2 diabetes in real-world clinical practice: insights from the DPV register – an IMI-SOPHIA study
There is significant heterogeneity in responses to GLP-1 RA therapy among individuals with type 2 diabetes in routine clinical practice. However, in our study a substantial proportion achieved a reduction in either body weight or HbA<sub>1c</sub>. Future studies should explore why some individuals achieve either weight loss or HbA<sub>1c</sub> reduction but not both.
Authors
- Martin Heni (ORCID: https://orcid.org/0000-0002-8462-3832)
- Gisa Ufer
- Jörg Reindel
- Reinhard W. Holl (ORCID: https://orcid.org/0000-0003-1395-4842)
- Christian von Wagner (ORCID: https://orcid.org/0000-0002-7971-0691)
- Kathrin Niemöller
- Jochen Seufert (ORCID: https://orcid.org/0000-0001-5654-7310)
- Michael Naudorf
- Nicole Prinz (ORCID: https://orcid.org/0000-0002-7570-9095)
- Lisa Frühwald
- Frank Pagnia
- Wölfram Karges
Institutions
- University of Freiburg (DE)
- Zimmer Biomet (Netherlands) (NL)
- Universität Ulm (DE)
- German Diabetes Center Mergentheim (DE)
- University Hospital Augsburg (DE)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- Kernkraftwerk Gundremmingen (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- University Hospital Ulm (DE)
- German Center for Diabetes Research (DE)
- Technische Hochschule Ulm (DE)
- Heinrich Heine University Düsseldorf (DE)
- Medical University of Vienna (AT)
- University of Tübingen (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1007/s00125-025-06448-w
- Citations
- 10
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 12.95
Funders
- Universität Ulm
- Robert Koch Institut