Identifying the germline variation spectrum and predisposition genes in Chinese ovarian cancer using whole exome sequencing
Using WES, we found that 28.26% of patients with OC had germline cancer-predisposing variations. WES substantially improved the detection rates of a wide spectrum of variations in OC patients and uncovered putative predisposition genes.
Authors
- Fenglan Zhang (ORCID: https://orcid.org/0000-0002-7155-0945)
- Hao Qiu (ORCID: https://orcid.org/0000-0002-6826-3734)
- Xiao Zhang (ORCID: https://orcid.org/0000-0002-7305-5278)
- Qian Zhu (ORCID: https://orcid.org/0000-0002-1203-3278)
- Lan Qin
- Xiaojing Guan
- Sheng Liao
Institutions
- Dian Diagnostics (China) (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s12885-025-14302-w
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Education of Zhejiang Province