Spatial multiomics decipher fibroblast–macrophage dynamics in systemic sclerosis
Our spatially resolved atlas uncovered dynamic fibroblast-macrophage interplay as a hallmark of fibrotic niche expansion. These findings offer spatiotemporal insights into disease mechanisms and pave the way for advanced mechanistic and therapeutic studies, bridging the gap between omics discovery and precision medicine.
Authors
- Hejian Zou (ORCID: https://orcid.org/0000-0001-9762-2663)
- Wenjie Xie (ORCID: https://orcid.org/0000-0001-9589-9431)
- Christina Bergmann (ORCID: https://orcid.org/0000-0001-5257-9171)
- Wenjing Ye (ORCID: https://orcid.org/0000-0003-1001-8880)
- Minrui Liang (ORCID: https://orcid.org/0000-0002-7650-1237)
- Jörg H. W. Distler (ORCID: https://orcid.org/0000-0001-7408-9333)
- Jiucun Wang (ORCID: https://orcid.org/0000-0003-2765-0620)
- Rui He (ORCID: https://orcid.org/0000-0002-2368-7269)
- Alexandru‐Emil Matei (ORCID: https://orcid.org/0000-0003-1248-3145)
- Luca Pinello (ORCID: https://orcid.org/0000-0003-1109-3823)
- Aleix Rius Rigau (ORCID: https://orcid.org/0000-0002-0871-306X)
- Zhijian Li (ORCID: https://orcid.org/0000-0002-1523-1333)
- Yinan Li (ORCID: https://orcid.org/0000-0001-8934-9361)
- Linlin Huang (ORCID: https://orcid.org/0000-0003-0317-4893)
- Xian Shao (ORCID: https://orcid.org/0000-0002-4301-0255)
Institutions
- Broad Institute (US)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Universitätsklinikum Erlangen (DE)
- Düsseldorf University Hospital (DE)
- Ningbo Medical Center Lihuili Hospital (CN)
- Comprehensive Cancer Center Erlangen (DE)
- Huashan Hospital (CN)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1016/j.ard.2025.04.025
- Citations
- 11
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 16.19
Funders
- Deutsche Forschungsgemeinschaft
- National Natural Science Foundation of China
- Fudan University
- Huashan Hospital