Histamine metabolite to basal serum tryptase ratios in systemic mastocytosis and hereditary alpha tryptasemia using a validated LC-MS/MS approach
Our LC-MS/MS method provides highly accurate and efficient quantification of histamine, NMH, and MIMA. Integrating BST/NMH and BST/MIMA ratios in diagnostic protocols enhances detection of HαT in MC-related disorders, supporting improved diagnostics and tailored patient management.
Authors
- Ido P. Kema (ORCID: https://orcid.org/0000-0003-1166-6169)
- Hanneke N.G. Oude Elberink
- Abdulrazzaq Alheraky (ORCID: https://orcid.org/0000-0002-0708-8987)
- Saskia K. Klein (ORCID: https://orcid.org/0000-0001-8847-2704)
- Martijn H. J. R. van Faassen (ORCID: https://orcid.org/0000-0002-9142-6263)
- Michel J. Vos (ORCID: https://orcid.org/0000-0001-9379-2219)
- Caroline Roozendaal (ORCID: https://orcid.org/0000-0001-7111-0379)
- André B. Mulder
- Claude P. van der Ley
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Dialyse Centrum Groningen (NL)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1515/cclm-2025-0189
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00