Pannexin-1 channels, extracellular ATP, and purinergic receptors are essential for CCR5/CXCR4 clustering and HIV entry
We conclude that gp120 binding to the cell induces Panx-1 opening to promote the clustering of CCR5 or CXCR4 to the site of CD4-gp120 contact to aid viral entry.
Authors
- Eliana Scemes (ORCID: https://orcid.org/0000-0002-6650-3976)
- Stephani Velasquez (ORCID: https://orcid.org/0000-0002-1561-828X)
- Eliseo A. Eugenín (ORCID: https://orcid.org/0000-0002-2925-4720)
- Antonio Cibelli (ORCID: https://orcid.org/0000-0001-5689-9885)
- David Ajasin (ORCID: https://orcid.org/0000-0003-1061-1860)
- David C. Spray (ORCID: https://orcid.org/0000-0001-8368-5073)
- Joy E. Gibson (ORCID: https://orcid.org/0000-0003-3976-2320)
Institutions
- Albert Einstein College of Medicine (US)
- Children's Hospital of Los Angeles (US)
- York University (US)
- The University of Texas Medical Branch at Galveston (US)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- NeuroImmune Pharmacology and Therapeutics
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1515/nipt-2025-0005
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke