Protocol digest of a single-arm confirmatory trial for less intensive postoperative surveillance in low-risk colorectal cancer patients: JCOG1915 (less study)
The Japanese Society for Cancer of the Colon and Rectum guidelines recommend intensive surveillance for curatively resected pathological stage I-III colorectal cancer. However, there is still no global consensus on the optimal method, duration, or frequency of surveillance, and no clinical trials have demonstrated the usefulness of surveillance. We are conducting a clinical trial to confirm the efficacy of less-intensive surveillance after R0 resection with lymph node dissection for stage I or low-risk stage II colorectal cancer in patients without risk factors for recurrence. If this less intensive surveillance method proves effective, medical costs will be considerably reduced. The primary endpoint is overall survival. A total of 680 patients will be enrolled from 59 institutions over 2 years. This trial has been registered at the Japan Registry of Clinical Trials (jRCT) as study number jRCT1030220350.
Authors
- Yasumasa Takii (ORCID: https://orcid.org/0000-0001-9712-8542)
- Konosuke Moritani (ORCID: https://orcid.org/0000-0001-6959-7210)
- Yusuke Sano (ORCID: https://orcid.org/0000-0001-6738-1854)
- Yukihide Kanemitsu (ORCID: https://orcid.org/0000-0002-3366-3826)
- Atsuo Takashima
- Haruhiko Fukuda (ORCID: https://orcid.org/0000-0002-6332-4745)
- Junki Mizusawa (ORCID: https://orcid.org/0000-0001-8123-5298)
- Shunsuke Tsukamoto (ORCID: https://orcid.org/0000-0001-5143-6312)
- Manabu Shiozawa (ORCID: https://orcid.org/0009-0006-1912-5948)
- Hideki Ueno (ORCID: https://orcid.org/0000-0001-7747-0738)
- Tomoko Kataoka (ORCID: https://orcid.org/0000-0003-4468-2632)
- Akio Shiomi (ORCID: https://orcid.org/0000-0001-5657-8686)
- Masaaki Ito (ORCID: https://orcid.org/0000-0002-1101-2707)
- Tetsuya Hamaguchi (ORCID: https://orcid.org/0009-0001-0798-1396)
- Dai Shida (ORCID: https://orcid.org/0000-0003-3294-1924)
- Yuichi Takayama (ORCID: https://orcid.org/0000-0002-7484-8480)
- Yuta Sekino (ORCID: https://orcid.org/0000-0001-8885-4972)
- Shin Fujita
- Satoshi Ikeda (ORCID: https://orcid.org/0000-0002-6285-6643)
- Makoto Kinouchi
Institutions
- Kanagawa Prefectural Hospital Organization (JP)
- Shizuoka Cancer Center (JP)
- National Cancer Center (US)
- Niigata Cancer Center Hospital (JP)
- Miyagi Prefectural Hospital Organization (JP)
- Hiroshima Prefectural Hospital (JP)
- Ogaki Municipal Hospital (JP)
- Tochigi Cancer Center (JP)
- Saitama International Medical Center (JP)
- National Cancer Center Hospital East (JP)
- Japan Clinical Cancer Research Organization (JP)
- Tokyo National Hospital (JP)
- Kanagawa Cancer Center
- National Defense Medical College (JP)
- The University of Tokyo (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Japanese Journal of Clinical Oncology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1093/jjco/hyaf077
- Citations
- 1
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Amgen
- Bristol-Myers Squibb
- AstraZeneca
- Japan Agency for Medical Research and Development
- Eisai