Human congenital cataract mutation in MYH9 alters F-actin organization and cell functions
The missense gene mutation in <i>MYH9</i> (p.E1384Q) causing congenital cataract results in decreased amount and altered subcellular distribution of NM IIA and F-actin, accompanied by decreased cell proliferation and migration, promotes apoptosis and mitochondrial alteration.
Authors
- Jiarui Yang (ORCID: https://orcid.org/0000-0001-8238-7699)
- Yuan Hao (ORCID: https://orcid.org/0000-0002-4802-3469)
- Xuemin Li (ORCID: https://orcid.org/0000-0001-7822-4694)
- Chen Huang (ORCID: https://orcid.org/0000-0002-4053-3552)
Institutions
- Beijing Tongren Hospital (CN)
- Peking University (CN)
- Peking University Third Hospital (CN)
- Tech Foundation (US)
Publication Details
- Journal
- International Journal of Ophthalmology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.18240/ijo.2025.06.01
- Citations
- 1
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.81