Exploring the mechanism of action of aspirin in improving endometrial receptivity in PCOS rats based on uterine lavage fluid metabolomics
Aspirin may enhance glucose metabolism, alleviate insulin resistance, promote angiogenesis, and improve vascular permeability and endometrial receptivity. These effects are likely mediated through the regulation of biomarkers involved in the pentose phosphate pathway, arginine and proline metabolism, and glycerophospholipid pathways in uterine lavage fluid.
Authors
- Shuo Yang (ORCID: https://orcid.org/0009-0002-4266-1838)
- Quan Liu (ORCID: https://orcid.org/0000-0002-8824-7440)
- Xi Wang (ORCID: https://orcid.org/0000-0002-7572-6354)
- Yiqing He
- Ying Zhang (ORCID: https://orcid.org/0000-0001-5476-1524)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1371/journal.pone.0324432
- Citations
- 2
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province