Boosting immune response against cervical cancer: A combined approach using oncolytic virus and targeted therapies

Our findings highlight the potential to improve outcomes in cervical cancer associated with HPV through a multi-faceted approach incorporating NDV, Everolimus, and Beclin-1. This therapeutic strategy not only hinders tumor growth but also strengthens the immune system's ability to fight against cancer. These results prompt further exploration of this combination in clinical trials, with the goal of offering new treatment avenues for patients who have limited choices.

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Publication Details

Journal
PLoS ONE
Published
2025-05-22
DOI
https://doi.org/10.1371/journal.pone.0312979
Primary Topic
Virus-based gene therapy research
Type
article
Field-Weighted Citation Impact
0.00

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article

Boosting immune response against cervical cancer: A combined approach using oncolytic virus and targeted therapies

Mohammad Shenagari, Amir Ghaemi, Hedieh Zargaran, Mehdi Samadi
PLoS ONE
Virus-based gene therapy research
article

Boosting immune response against cervical cancer: A combined approach using oncolytic virus and targeted therapies

Mohammad Shenagari, Amir Ghaemi, Hedieh Zargaran, Mehdi Samadi
article en

Abstract

Our findings highlight the potential to improve outcomes in cervical cancer associated with HPV through a multi-faceted approach incorporating NDV, Everolimus, and Beclin-1. This therapeutic strategy not only hinders tumor growth but also strengthens the immune system's ability to fight against cancer. These results prompt further exploration of this combination in clinical trials, with the goal of offering new treatment avenues for patients who have limited choices.

PLoS ONEVol. 20(5)
Pasteur Institute of Iran (IR), Guilan University of Medical Sciences (IR), Mazandaran University of Medical Sciences (IR)
Guilan University of Medical Sciences, Pasteur Institute of Iran
Good health and well-being
Openalex Percentile: Top 87%
Virus-based gene therapy research
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