Scavenger receptor class B type I knockout mice develop extensive diet-induced coronary artery atherosclerosis in an age-dependent manner
HFCC diet-fed homozygous SR-B1 knockout mice develop occlusive coronary artery atherothrombosis and myocardial fibrosis in an age-dependent manner, and exhibit an increased inflammatory state with older age. Therefore, aged SR-B1 knockout mice may prove to be an attractive mouse model to analyze age-dependent mechanisms associated with coronary artery disease development, which may facilitate the discovery of more effective therapeutics to treat cardiovascular disease.
Authors
- Mark Fuller (ORCID: https://orcid.org/0000-0001-7631-2930)
- Bibi S.H. Sokeechand
- Suleiman A. Igdoura (ORCID: https://orcid.org/0000-0001-8780-4981)
- Ting Xiong (ORCID: https://orcid.org/0000-0002-0004-7322)
- Richard C. Austin (ORCID: https://orcid.org/0000-0003-0127-0865)
- Samuel K. Lee (ORCID: https://orcid.org/0000-0003-0717-1163)
- Peter L. Gross (ORCID: https://orcid.org/0000-0002-8698-7074)
- Bernardo L. Trigatti (ORCID: https://orcid.org/0000-0002-4556-119X)
- Alexander S. Qian (ORCID: https://orcid.org/0000-0001-7709-391X)
- Jeong‐Ah Yoo
Institutions
- Thrombosis and Atherosclerosis Research Institute (CA)
- St. Joseph’s Healthcare Hamilton (CA)
- McMaster University (CA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1371/journal.pone.0318118
- Citations
- 1
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Canadian Institutes of Health Research