TEMPO-Mediated Polyyne Cyclization
In this work, we report the cyclization of sulfur-linked tetraynes under 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) radical conditions, leading to the formation of novel pentadehydro-Diels-Alder-type addition products. Through this study, we expand the scope of radical-mediated cyclization reactions of polyyne compounds. The results offer new opportunities for the development of radical-based synthetic methodologies.
Authors
- Chenlong Zhu (ORCID: https://orcid.org/0000-0003-4564-3117)
- Ying Xia (ORCID: https://orcid.org/0000-0002-0126-6594)
- Bingfeng Sun
- Qi Liang (ORCID: https://orcid.org/0000-0002-3652-7360)
Institutions
- Nanjing Tech University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1021/acs.orglett.5c00651
- Citations
- 2
- Primary Topic
- Cyclization and Aryne Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.87