Kynurenine pathway metabolite alterations in Down syndrome and Alzheimer's disease
There are altered kynurenine pathway metabolites in Down syndrome and Alzheimer's disease. Elevated neuroprotective metabolites are found in Down syndrome without cognitive decline. Significant differences in neurotoxic metabolites among study groups were analyzed. There is a potential link between kynurenine pathway dysregulation and cognitive decline. The study provides insights into metabolic changes in aging and neurodegeneration.
Authors
- Wagner F. Gattaz (ORCID: https://orcid.org/0000-0001-5215-4077)
- Rafael Menezes-Reis (ORCID: https://orcid.org/0000-0002-8496-5939)
- Monique Patrício Singulani (ORCID: https://orcid.org/0000-0001-7019-0485)
- Orestes Vicente Forlenza (ORCID: https://orcid.org/0000-0002-6962-5899)
- Leda Leme Talib (ORCID: https://orcid.org/0000-0001-5866-1993)
Institutions
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
- Universidade de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70197
- Citations
- 6
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.47
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Universidade de São Paulo
- Faculdade de Medicina da Universidade de São Paulo