Physical and biopsychosocial frailty, cognitive phenotypes, and plasma biomarkers for Alzheimer's disease in Chinese older adults: A population‐based study
Physical (PF) and biopsychosocial frailty (BF) were strongly associated with dementia and mild cognitive impairment (MCI) in rural Chinese older adults. Frailty, especially PF, was associated with increased plasma phosphorylated tau 217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) and a reduced plasma amyloid-β (Aβ)42/Aβ40 ratio. Alzheimer's pathology, neuroinflammation, and neurodegeneration may underlie the associations of frailty with dementia. PF, in combination with demographic factors, performed excellent (area under the curve [AUC] = 0.83) in differentiating dementia from non-dementia in rural older adults.
Authors
- Yixun Ma
- Yifeng Du (ORCID: https://orcid.org/0000-0002-4672-6654)
- Lin Song (ORCID: https://orcid.org/0000-0001-9500-8387)
- Na Tian (ORCID: https://orcid.org/0000-0001-5627-5095)
- Shi Tang (ORCID: https://orcid.org/0000-0003-4241-6058)
- Lin Shi (ORCID: https://orcid.org/0000-0002-4934-6649)
- Chengxuan Qiu (ORCID: https://orcid.org/0000-0003-1922-4912)
- Min Zhu (ORCID: https://orcid.org/0000-0002-7468-0083)
- Davide Liborio Vetrano (ORCID: https://orcid.org/0000-0002-3099-4830)
- Lin Cong (ORCID: https://orcid.org/0009-0003-1278-1334)
- Nan Wang (ORCID: https://orcid.org/0009-0006-1132-8054)
- Yongxiang Wang (ORCID: https://orcid.org/0000-0002-8832-7301)
- Cuicui Liu (ORCID: https://orcid.org/0000-0002-5960-5851)
- Tingting Hou (ORCID: https://orcid.org/0000-0003-2614-8145)
- Xunyao Tian
- Heng Zhang (ORCID: https://orcid.org/0009-0007-6751-7062)
Institutions
- Shandong University (CN)
- Stockholm University (SE)
- Karolinska Institutet (SE)
- Shandong Provincial Hospital (CN)
- Stockholm Gerontology Research Center Foundation (SE)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70303
- Citations
- 2
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 2.45
Funders
- Swedish Foundation for International Cooperation in Research and Higher Education
- National Natural Science Foundation of China
- Vetenskapsrådet
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Natural Science Foundation of Shandong Province
- Shandong First Medical University
- Postdoctoral Innovation Project of Shandong Province