Slow wave synchrony during NREM sleep tracks cognitive impairment in prodromal Alzheimer's disease
Detailed analysis of high-density sleep electroencephalography was performed in amnestic mild cognitive impairment and Alzheimer's disease (AD) patients. Cognitive status robustly correlates with slow wave trough and its cortical spread. Delayed rapid eye movement sleep onset associated with AD correlates with diminished slow wave troughs. Impaired slow waves mark progressively disrupted neural activity in prodromal AD.
Authors
- Riva Tauman (ORCID: https://orcid.org/0000-0002-6574-3601)
- Rotem Falach
- Tamara Shiner (ORCID: https://orcid.org/0000-0002-6368-9656)
- Noa Bregman (ORCID: https://orcid.org/0000-0003-4856-086X)
- Yuval Nir (ORCID: https://orcid.org/0000-0002-5433-6349)
- Matthew P. Walker (ORCID: https://orcid.org/0000-0002-7839-6389)
- O. Sharon (ORCID: https://orcid.org/0000-0003-1403-380X)
- Yael Gat
- Vladislav Zhelezniakov
- Darya Narbayev
Institutions
- Tel Aviv University (IL)
- Tel Aviv Sourasky Medical Center (IL)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70247
- Citations
- 5
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 7.16
Funders
- Glenn Foundation for Medical Research
- European Research Council