AP1-mediated reprogramming of EGFR expression triggers resistance to BLU-667 and LOXO-292 in RET-rearranged tumors

This study elucidates EGFR's role in mediating resistance to RET inhibitors in NSCLC patients. These findings offer insights into therapeutic adaptation and explore personalized combinations of RET and EGFR inhibitors for improved clinical outcomes.

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Publication Details

Journal
Journal of Experimental & Clinical Cancer Research
Published
2025-05-22
DOI
https://doi.org/10.1186/s13046-025-03392-w
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00

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article

AP1-mediated reprogramming of EGFR expression triggers resistance to BLU-667 and LOXO-292 in RET-rearranged tumors

Stefania Belli, Umberto Malapelle, Benjamin Besse, Daniela Esposito et al.
Journal of Experimental & Clinical Cancer Research
Lung Cancer Treatments and Mutations
article

AP1-mediated reprogramming of EGFR expression triggers resistance to BLU-667 and LOXO-292 in RET-rearranged tumors

Stefania Belli, Umberto Malapelle, Benjamin Besse, Daniela Esposito, Emilio Bria, Giancarlo Troncone, Antonino Iaccarino, Diletta Barone, Roberto Bianco, Felice Pepe, Luigi Formisano, Mihaela D. Aldea, Alberto Servetto, Daniele Lorenzini, Fabiana Napolitano, Maria‐Rosa Ghigna, Arianna Marinello, Claudia Maria Ascione, Giuseppe Lo Russo, Roberto Ferrara
article en

Abstract

This study elucidates EGFR's role in mediating resistance to RET inhibitors in NSCLC patients. These findings offer insights into therapeutic adaptation and explore personalized combinations of RET and EGFR inhibitors for improved clinical outcomes.

Journal of Experimental & Clinical Cancer ResearchVol. 44(1)
Vita-Salute San Raffaele University (IT), Université Paris-Saclay (FR), Institut Gustave Roussy (FR), Agostino Gemelli University Polyclinic (IT), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), University of Naples Federico II (IT)
Ministero della Salute, Associazione Italiana per la Ricerca sul Cancro, Università Cattolica del Sacro Cuore, Ministero dell'Università e della Ricerca
Good health and well-being
Openalex Percentile: Top 81%
Lung Cancer Treatments and Mutations
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