AP1-mediated reprogramming of EGFR expression triggers resistance to BLU-667 and LOXO-292 in RET-rearranged tumors
This study elucidates EGFR's role in mediating resistance to RET inhibitors in NSCLC patients. These findings offer insights into therapeutic adaptation and explore personalized combinations of RET and EGFR inhibitors for improved clinical outcomes.
Authors
- Stefania Belli (ORCID: https://orcid.org/0000-0002-8348-3313)
- Umberto Malapelle (ORCID: https://orcid.org/0000-0003-3211-9957)
- Benjamin Besse (ORCID: https://orcid.org/0000-0001-5090-8189)
- Daniela Esposito (ORCID: https://orcid.org/0000-0001-5211-9861)
- Emilio Bria (ORCID: https://orcid.org/0000-0002-2333-704X)
- Giancarlo Troncone (ORCID: https://orcid.org/0000-0003-1630-5805)
- Antonino Iaccarino
- Diletta Barone (ORCID: https://orcid.org/0000-0003-1666-5210)
- Roberto Bianco (ORCID: https://orcid.org/0000-0003-3311-260X)
- Felice Pepe (ORCID: https://orcid.org/0000-0001-6507-9993)
- Luigi Formisano (ORCID: https://orcid.org/0000-0001-7205-5105)
- Mihaela D. Aldea (ORCID: https://orcid.org/0000-0001-7685-051X)
- Alberto Servetto (ORCID: https://orcid.org/0000-0003-3624-224X)
- Daniele Lorenzini (ORCID: https://orcid.org/0000-0002-1425-3354)
- Fabiana Napolitano (ORCID: https://orcid.org/0000-0002-9242-6046)
- Maria‐Rosa Ghigna (ORCID: https://orcid.org/0000-0001-5996-665X)
- Arianna Marinello (ORCID: https://orcid.org/0000-0003-3966-1984)
- Claudia Maria Ascione (ORCID: https://orcid.org/0009-0000-9454-2828)
- Giuseppe Lo Russo (ORCID: https://orcid.org/0000-0003-3224-2728)
- Roberto Ferrara (ORCID: https://orcid.org/0000-0001-6443-5642)
Institutions
- Vita-Salute San Raffaele University (IT)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Agostino Gemelli University Polyclinic (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s13046-025-03392-w
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro
- Università Cattolica del Sacro Cuore
- Ministero dell'Università e della Ricerca