Macrophage pyroptosis mediates hyperoxia-induced inflammatory lung injury in neonates
NLRP3/Caspase-1/GSDMD-mediated pyroptosis plays a critical role in hyperoxia-induced neonatal lung injury, and targeting this pathway may be beneficial for the prevention of lung injury in preterm infants.
Authors
- Zikun Tu
- Yajing Gao
- Qiuyan Liang (ORCID: https://orcid.org/0000-0002-0405-9005)
- Yufeng Zhou (ORCID: https://orcid.org/0000-0002-6050-4951)
- Wenfeng Xiao (ORCID: https://orcid.org/0000-0002-4369-9371)
- Hongmiao Yu (ORCID: https://orcid.org/0000-0001-9952-4370)
- Xueru Xie
- Haiyan Guo (ORCID: https://orcid.org/0000-0002-1952-2648)
Institutions
- Fudan University (CN)
- National Health and Family Planning Commission (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1546986
- Citations
- 6
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 9.11