CD46 TREM1 regulates the autophagy marker LC3B ATG5 in oral squamous cell carcinoma
OSCC cells have high expression of CD46 and TREM1, while low expression of LC3B and ATG5, and the autophagy apoptosis signal is weakened. Interfering with CD46 can up-regulate the expression of autophagy apoptosis genes, reduce the tumor inflammatory microenvironment, induce the apoptosis of OSCC cells, and inhibit the proliferation and metastasis of OSCC. This study provides a new idea for the mechanism and targeted therapy of OSCC and has important theoretical significance and clinical application value.
Authors
- Meihua Gao (ORCID: https://orcid.org/0000-0003-3705-6035)
- Beibei Cong
- Xiaofang Lv (ORCID: https://orcid.org/0000-0003-2316-4537)
- Wanchun Wang (ORCID: https://orcid.org/0000-0002-0610-4180)
- Xiaodan Liu
- Yuanfei Wang (ORCID: https://orcid.org/0000-0003-4134-307X)
- Fumin Zheng
Institutions
- Qingdao University (CN)
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fonc.2025.1579282
- Citations
- 1
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.80