Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway
Our results indicate THBS1 regulates mechanical stress-induced chondrocyte ferroptosis through the Integrin/YAP pathway. Furthermore, THBS1 effectively slows the progression of osteoarthritis and protects articular cartilage.
Authors
- Yongyuan Guo (ORCID: https://orcid.org/0009-0001-7166-8978)
- Yuanqiang Zhang (ORCID: https://orcid.org/0000-0002-4592-4966)
- Fujian Zhang (ORCID: https://orcid.org/0000-0003-4552-9509)
- Shaoyi Wang (ORCID: https://orcid.org/0000-0002-7987-5795)
- Haoxin Zhai
- Xiaocong Zhou
Institutions
- Shandong Provincial Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- First Affiliated Hospital of Jinan University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1577234
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81