Epithelial-to-mesenchymal transition is an active process in the large airways of patients with asthma-COPD overlap and partially abrogated by inhaled corticosteroid treatment: a bronchoscopy endobronchial biopsy study
These data are suggestive of active EMT in ACO. Additionally, 50% of the patients with ACO were on 800 mcg/day inhaled corticosteroid (ICS) treatment which may have abrogated some EMT activity; however, it suggests protective effects of ICS as we previously reported in COPD. Studies with larger cohorts are needed to further confirm ICS effects in ACO.
Authors
- Maddison Waters
- Greg Haug
- Peter A. B. Wark (ORCID: https://orcid.org/0000-0001-5676-6126)
- Mathew Suji Eapen (ORCID: https://orcid.org/0000-0003-0570-7059)
- Heinrich C. Weber (ORCID: https://orcid.org/0000-0003-0290-0355)
- Wenying Lu (ORCID: https://orcid.org/0000-0002-3246-9108)
- Josie Larby
- Prabuddha S. Pathinayake (ORCID: https://orcid.org/0000-0002-4947-5918)
- Sukhwinder Singh Sohal (ORCID: https://orcid.org/0000-0001-9627-6498)
- Surajit Dey (ORCID: https://orcid.org/0009-0003-6478-1336)
Institutions
- University of Tasmania (AU)
- Launceston General Hospital (AU)
- North West Regional Hospital (AU)
- Hunter Medical Research Institute (AU)
- Monash University (AU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1531279
- Citations
- 3
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Clifford Craig Foundation