Evaluation of the efficacy and safety of dapsone alone or associated with topical corticosteroids for pemphigus foliaceus: a retrospective multicentre study
This retrospective series is the largest one to date, with the longest follow-up, to study the efficacy and safety of dapsone in patients with pemphigus foliaceus (PF). The results of this study indicate that dapsone’s long-term efficacy for PF is modest, whether used alone or in combination with topical corticosteroids, even for mild cases, and is associated with a high rate of adverse events. Dapsone may still be appropriate for patients with mild PF who have contraindications to immunosuppressive therapies; in other situations, alternative systemic therapies, particularly rituximab, should be considered.
Authors
- S. Tzoumpa (ORCID: https://orcid.org/0000-0002-8129-5933)
- Irène Gallais-Sérézal
- D. Boutin (ORCID: https://orcid.org/0000-0003-1935-2033)
- Perrine Rousseau
- E. Mahé (ORCID: https://orcid.org/0000-0001-5780-1827)
- O. Dereure (ORCID: https://orcid.org/0000-0001-8736-1922)
- S. Oro (ORCID: https://orcid.org/0000-0002-5383-7096)
- Emmanuelle Tancrède‐Bohin (ORCID: https://orcid.org/0000-0002-0412-0806)
- N. Cordel (ORCID: https://orcid.org/0000-0003-1679-8005)
- C. Lepelletier (ORCID: https://orcid.org/0000-0003-3204-9194)
- F. Caux (ORCID: https://orcid.org/0000-0001-9552-0882)
- F. Lombart
- A. Brue
- C. Berthin (ORCID: https://orcid.org/0000-0003-3824-9381)
- N. Litrowski
- G. Jeudy (ORCID: https://orcid.org/0009-0003-7065-9097)
- J. Bouteiller (ORCID: https://orcid.org/0000-0002-5989-9693)
- S. Duvert‐Lehembre (ORCID: https://orcid.org/0000-0001-8331-7000)
- G. Bohelay (ORCID: https://orcid.org/0000-0002-8792-979X)
- M. Viguier
- Cathérine Prost (ORCID: https://orcid.org/0000-0002-2873-7237)
- M. Alexandre (ORCID: https://orcid.org/0000-0003-0155-9239)
- V. Seta (ORCID: https://orcid.org/0000-0002-3252-5333)
- Pascal Joly (ORCID: https://orcid.org/0000-0002-8079-5004)
- Christelle Le Roux-Villet
Institutions
- Université Le Havre Normandie (FR)
- Université Paris-Est Créteil (FR)
- Nord University (NO)
- Université de Poitiers (FR)
- Centre Hospitalier Universitaire de Besançon (FR)
- Hôpital Charles-Nicolle (FR)
- Université Sorbonne Paris Nord (FR)
- Hôpital Cochin (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Universitaire de Reims (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Hôpital Nord (FR)
- Centre Hospitalier Victor Dupouy (FR)
- Maison des Sciences sociales et des Humanités de Dijon (FR)
- Hôpital Saint-Louis (FR)
- Centre Hospitalier Départemental Vendée (FR)
- Institut Pasteur de la Guadeloupe (GP)
- Roche (Bosnia-Herzegovina) (BA)
- Université d'Angers (FR)
- Université de Reims Champagne-Ardenne (FR)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1093/bjd/ljaf190
- Primary Topic
- Autoimmune Bullous Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00