The Impact of the Appendix on Intestinal Microbiome and Colorectal Cancer

阑尾切除术在结直肠癌(CRC)发病机制中的作用是近期争议的焦点。鉴于阑尾切除术仍是最常见的外科手术之一，也是急性阑尾炎的一线治疗策略，阐明既往阑尾切除术与后续结直肠癌发生之间的关联具有重要的临床意义，因其可能产生远期健康影响。本综述旨在整合阑尾切除术后患者结直肠癌相关性的研究证据，探讨微生物组在阑尾切除术与结直肠癌发病机制中的潜在作用，并对当前关于阑尾功能的认知进行评估。The potential association between appendectomy and colorectal cancer (CRC) pathogenesis has emerged as a subject of ongoing scientific debate. Given that appendectomy remains one of the most prevalent surgical procedures worldwide and constitutes the first-line therapeutic intervention for acute appendicitis, elucidating the causal relationship between prior appendectomy and subsequent colorectal carcinogenesis carries substantial clinical implications due to its potential long-term health consequences. This systematic review seeks to synthesize existing evidence regarding CRC susceptibility in post-appendectomy cohorts, investigate the potential mediating role of microbiome dysbiosis in appendectomy-associated CRC pathogenesis, and reassess current perspectives on the appendix’s immunological functions through the lens of oncogenic transformation.