Anti-Senescence Effect of Inhibiting Sodium-Glucose Cotransporter 2 and α-Glucosidase in a Type 2 Diabetes Mellitus Animal Model
The combined administration of enavogliflozin and acarbose significantly reduced blood glucose, improved β-cell function, and reduced senescent β-cells in db/db mice. This combination therapy holds potential as a senotherapeutic strategy for managing T2DM.
Authors
- Sang-Wan Hong (ORCID: https://orcid.org/0009-0008-1010-1522)
- Young Min Cho (ORCID: https://orcid.org/0000-0002-2331-6126)
- Byung Soo Kong (ORCID: https://orcid.org/0000-0002-7916-7422)
- Hyunsuk Lee (ORCID: https://orcid.org/0000-0001-9751-5868)
Institutions
- Seoul National University (KR)
- Seoul National University Hospital (KR)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-05-22
- DOI
- https://doi.org/10.4093/dmj.2024.0339
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Research Foundation
- Seoul National University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Seoul National University Hospital
- Daewoong Pharmaceutical Company
- Ministry of Science and ICT, South Korea