TIM3 and TIGIT-expressing CD4 T cells are impacted by kidney transplantation and associated with risk of infection
Increased frequency of TIM3 and TIGIT markers associated with T cell experience and senescence was a notable phenotypic change associated with transplantation and induction and maintenance immunosuppression. Incorporation of TIGIT expression and induction type into an infection prediction model holds promise for risk stratification and individualization of immunosuppression to decrease risk of adverse outcomes, especially for older patients.
Authors
- Harry Pickering (ORCID: https://orcid.org/0000-0003-2348-5410)
- Monica Cappelletti
- Suphamai Bunnapradist
- Elaine F. Reed (ORCID: https://orcid.org/0000-0002-3524-545X)
- Joanna Schaenman (ORCID: https://orcid.org/0000-0003-1174-3961)
- Erik L. Lum (ORCID: https://orcid.org/0000-0001-9495-8225)
- Subha Sen
Institutions
- University of California, Los Angeles (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1550154
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Mendez National Institute of Transplantation Foundation
- National Institutes of Health
- National Institute on Aging
- National Institute of Allergy and Infectious Diseases