Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease
Despite the increasing incidence of Crohn's disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD, and compared their gene expression profile to healthy individuals. The main aim of our study was to perform an exploratory analysis of how the subclinical inflammatory process is modifying the individual's immunologic environment while the patient is still in the preclinical period.
Authors
- Asís Palazón (ORCID: https://orcid.org/0000-0002-7172-7229)
- Leire Egia‐Mendikute (ORCID: https://orcid.org/0000-0002-6435-1219)
- Iago Rodríguez–Lago (ORCID: https://orcid.org/0000-0003-1133-4578)
- Urko M. Marigorta (ORCID: https://orcid.org/0000-0002-9087-6609)
- Dimitrios Kioroglou (ORCID: https://orcid.org/0000-0003-3495-4585)
- Manuel Barreiro-de Acosta
Institutions
- Ikerbasque (ES)
- Universidad de Deusto (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- CIC bioGUNE (ES)
- Hospital de Galdakao (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1539830
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eusko Jaurlaritza
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- European Regional Development Fund
- Agencia Estatal de Investigación