Stevens–Johnson syndrome induced by Sintilimab: a case report and literature review
Although severe drug rash, including SJS, caused by PD-1 inhibitors is relatively uncommon, its underlying molecular pathogenesis remains unclear. Physicians should remain vigilant regarding potential adverse reactions when prescribing Sintilimab. If severe reactions occur, discontinuation of chemotherapy and immediate administration of adequate corticosteroids with symptomatic support can help reduce morbidity and mortality.
Authors
- Dongbei Huang
- Xunjin Zhu (ORCID: https://orcid.org/0000-0001-7929-6964)
- Chuxiang Hu
- Zihua Yu (ORCID: https://orcid.org/0000-0001-5137-7842)
- Gang Huang (ORCID: https://orcid.org/0000-0002-5786-7110)
- Liping Gong (ORCID: https://orcid.org/0000-0003-4626-6165)
- Hai-yun Lan
- Huan Kuang
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fonc.2025.1568316
- Citations
- 2
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Natural Science Foundation of Jiangxi Province