CBD promotes antitumor activity by modulating tumor immune microenvironment in HPV associated head and neck squamous cell carcinoma
CBD inhibits tumor cell proliferation in HPV-positive HNSCC by activating the MAPK pathway. It also enhances anti-tumor activity by modulating the tumor immune microenvironment, promoting co-localization of p38 MAPK-activated CD4+ and CD8+ T cells.
Authors
- Prakriti Sen (ORCID: https://orcid.org/0000-0003-0761-9378)
- Robert Saddawi‐Konefka (ORCID: https://orcid.org/0000-0002-9936-1695)
- Joseph A. Califano (ORCID: https://orcid.org/0000-0002-4715-6761)
- Sayuri Miyauchi
- Koji Ebisumoto (ORCID: https://orcid.org/0000-0002-6719-9443)
- Pardis Mohammadzadeh (ORCID: https://orcid.org/0000-0001-8704-1064)
- Andrew B. Sharabi (ORCID: https://orcid.org/0000-0003-2075-1197)
- Katrin Susanne Lips (ORCID: https://orcid.org/0000-0003-3320-7545)
- Roy S (ORCID: https://orcid.org/0000-0002-0411-1221)
- Riyam Al-Msari
- Sayed Sadat
- Takuya Nakagawa (ORCID: https://orcid.org/0000-0002-4623-9696)
Institutions
- University of California San Diego (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1528520
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 5.64