Comparative analysis of neutrophil dynamics and disease in SARS-CoV-2 Delta and Omicron variants utilizing an in vivo feline model for COVID-19
This study underscores the importance of variant-specific immune responses and highlights the need for targeted therapeutic strategies that mitigate severe lung injury associated with Delta infection, while also considering the distinct immune dynamics observed with the Omicron variant. Furthermore, results support the importance of delineating immune responses concerning future variants. These findings provide valuable insights into the pathogenesis of SARS-CoV-2 in companion animals and inform public health strategies as new variants continue to emerge.
Authors
- Craig Miller (ORCID: https://orcid.org/0000-0002-3638-5665)
- Sachithra Gunasekara (ORCID: https://orcid.org/0009-0009-9017-2538)
- Sunil Shivaji More (ORCID: https://orcid.org/0000-0001-5007-8795)
- Shoroq Shatnawi
- Jennifer Rudd (ORCID: https://orcid.org/0000-0002-4532-3458)
- Sai Narayanan (ORCID: https://orcid.org/0000-0002-3343-6797)
- Miruthula Tamil Selvan (ORCID: https://orcid.org/0000-0002-5412-5496)
- Breya Ludwig
Institutions
- Oklahoma State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1547918
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Oklahoma State University
- National Institutes of Health
- National Institute of General Medical Sciences