Nonlinearity and sex differences in the performance of a polygenic risk score for juvenile idiopathic arthritis
The relationship between PRS and JIA was slightly logit-nonlinear for females and logit-linear for males. The PRS for JIA can likely be used either as a continuous or discrete variable in analyses, but sex-stratification is recommended for future studies.
Authors
- Sigrid Valen Hestetun (ORCID: https://orcid.org/0009-0004-4199-4950)
- Piotr Jahołkowski (ORCID: https://orcid.org/0000-0001-9408-3107)
- Hamid Khoshfekr Rudsari (ORCID: https://orcid.org/0000-0002-7856-0038)
- Helga Sanner (ORCID: https://orcid.org/0000-0001-7226-066X)
- Kristine L. Haftorn (ORCID: https://orcid.org/0000-0002-2152-1839)
- V.Ø. Dåstøl
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-4461-3568)
- Clarice Ring Weinberg (ORCID: https://orcid.org/0000-0002-7713-8556)
Institutions
- Oslo University Hospital (NO)
- National Institutes of Health (US)
- University of Oslo (NO)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1531390
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Stiftelsen Kristian Gerhard Jebsen
- Trond Mohn stiftelse
- Novo Nordisk
- Universitetet i Bergen
- Norges Forskningsråd
- Helse Sør-Øst RHF
- Norwegian Institute of Public Health