Immunomodulatory effects of alpha vs beta radiopharmaceutical therapy in murine prostate cancer
Alpha-emitting <sup>225</sup>Ac-NM600 demonstrated superior ability to enhance antitumor immunity compared to beta-emitting <sup>177</sup>Lu-NM600. These findings support the use of <sup>225</sup>Ac-NM600 in combination with immunotherapies for advanced prostate cancer treatment.
Authors
- Ohyun Kwon (ORCID: https://orcid.org/0000-0002-0334-105X)
- Amanda M. Carston
- Anna S. Thickens
- Jamey P. Weichert (ORCID: https://orcid.org/0000-0002-2048-6381)
- Douglas G. McNeel (ORCID: https://orcid.org/0000-0003-1471-6723)
- Justin J. Jeffery
- Cynthia Choi (ORCID: https://orcid.org/0000-0002-5881-8150)
- Zachary S. Morris (ORCID: https://orcid.org/0000-0001-5558-3547)
- Caroline P. Kerr (ORCID: https://orcid.org/0000-0002-2389-9229)
- Zachary T. Rosenkrans (ORCID: https://orcid.org/0000-0002-7958-3645)
- Malick Bio Idrissou (ORCID: https://orcid.org/0009-0001-0437-6668)
- Mojdeh Mahmoudian
- Reinier Hernandez (ORCID: https://orcid.org/0000-0002-0729-2179)
- Bryan P. Bednarz (ORCID: https://orcid.org/0000-0002-7467-9816)
- Hemanth K. Potluri (ORCID: https://orcid.org/0000-0002-3646-4961)
- Carolina A. Ferreira (ORCID: https://orcid.org/0000-0002-5895-8508)
- Anatoly N. Pinchuk (ORCID: https://orcid.org/0009-0000-4684-7758)
- Joseph J. Grudzinski (ORCID: https://orcid.org/0000-0002-8799-1649)
- Nathan B Clemons
- Christopher F. Massey (ORCID: https://orcid.org/0000-0001-9321-1955)
Institutions
- University of Wisconsin System (US)
- University of Wisconsin–Madison (US)
- University of Wisconsin Carbone Cancer Center (US)
- Michigan State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1563387
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Institutes of Health
- National Cancer Institute