Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer
Our findings highlight the role of elevated epithelial amino acid metabolism in shaping an immune-suppressive microenvironment, offering insights for patient stratification and therapeutic decision-making.
Authors
- Tian-Yue Sun
- Yan Chen (ORCID: https://orcid.org/0000-0003-1027-6054)
- Ying Xuan Chen
Institutions
- University of Electronic Science and Technology of China (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- State Key Laboratory of Oncogene and Related Genes (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1575829
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University