HMGA2 interacts with KAT6A to regulate MMPs chromatin architecture and promote triple-negative breast cancer metastasis
These findings establish that the HMGA2/KAT6A complex promote MMPs expression to drive TNBC metastasis, identifying novel therapeutic targets for this aggressive malignancy.
Authors
- Lin Yu (ORCID: https://orcid.org/0000-0002-9972-3799)
- Wenjun Luo (ORCID: https://orcid.org/0000-0003-2811-1848)
- Shanshan Zhang (ORCID: https://orcid.org/0000-0002-9033-3786)
- Lu Qiao (ORCID: https://orcid.org/0000-0002-9037-5927)
- Zhenglun Liang (ORCID: https://orcid.org/0000-0002-6740-0864)
- Cuiyun Sun
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1590368
- Citations
- 2
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China