Development of a Japanese polygenic risk score model for amyloid-β PET imaging in Alzheimer’s disease
These findings highlight the potential of PRS as a noninvasive tool for early detection and risk stratification of AD, which could lead to enhanced clinical applications and interventions.
Authors
- Jun‐ichi Ito (ORCID: https://orcid.org/0000-0003-0673-9474)
- Kenji Tai
- Junro Kuromitsu
- Shogyoku Bun (ORCID: https://orcid.org/0000-0002-0815-1431)
- Kentaro Takahashi (ORCID: https://orcid.org/0000-0002-4296-8875)
- Daisuke Ito (ORCID: https://orcid.org/0000-0003-1924-3849)
- Misato Kaishima
Institutions
- Keio University (JP)
- Eisai (Japan) (JP)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s13195-025-01754-2
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Japan Agency for Medical Research and Development
- Keio University
- Eisai
- National Center for Geriatrics and Gerontology
- Japan Science and Technology Agency
- National Bioscience Database Center