Dysregulated lipids homeostasis disrupts CHAC1-mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer
Dysregulated lipid homeostasis downregulated CHAC1-mediated ferroptosis, leading to FGFR-TKI resistance in gastric cancer. Overexpression of CHAC1 or inhibiting cholesterol synthesis presents promising therapeutic strategies to overcome FGFR-TKI resistance in GC.
Authors
- Ling Ma (ORCID: https://orcid.org/0000-0002-1485-8994)
- Yun Chen (ORCID: https://orcid.org/0000-0002-4118-362X)
- Dongmei Zuo (ORCID: https://orcid.org/0009-0005-1112-2702)
- Songmao Li
- Yedi Huang
- Yongqian Shu (ORCID: https://orcid.org/0000-0003-2103-0877)
- Ran Li (ORCID: https://orcid.org/0000-0002-3636-3714)
- Jingwen Chen (ORCID: https://orcid.org/0000-0002-5756-3336)
- Dong Hua (ORCID: https://orcid.org/0000-0003-4265-5702)
- Xudong Song (ORCID: https://orcid.org/0000-0003-0178-0320)
- Qiang Zhan
- Pei Ma
- Guoquan Tao
- Ruimin Shan
Institutions
- Soochow University (CN)
- Huaian First People’s Hospital (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1016/j.redox.2025.103693
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52