Onboard, tethered IL-12 boosts potency of the Tmod NOT gate and preserves selectivity
We conclude that the mem-IL-12 module can be combined with multiple Tmod constructs to boost efficacy and persistence while preserving the on-tumor selectivity.
Authors
- Alexander C. Partin (ORCID: https://orcid.org/0000-0001-5641-8017)
- Richele Bruno
- Sanam Shafaattalab (ORCID: https://orcid.org/0000-0002-1127-8409)
- Mark Daris (ORCID: https://orcid.org/0000-0002-3879-8375)
- Alexander Kamb (ORCID: https://orcid.org/0000-0002-8675-6620)
- Jingli A. Zhang
- Dongwoo Lee (ORCID: https://orcid.org/0000-0001-5175-5954)
- Jianying Liang (ORCID: https://orcid.org/0000-0003-1752-4954)
- Sara Imboden (ORCID: https://orcid.org/0000-0002-9185-652X)
- Jon Torres
- Timothy P. Riley
Institutions
- UCLA Medical Center (US)
- Integrated BioTherapeutics (United States) (US)
- Nanotherapeutics (United States) (US)
- IntraMedical Imaging (United States) (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1136/jitc-2024-010976
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09